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Arthritis is a Collagen Tissue Disease

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Science stars
 

A meeting celebrating science, which starred two top Massey researchers, was hosted at Parliament recently by Science and Technology Minister and Massey Alumnus Pete Hodgson.

Institute of Fundamental Sciences' Professor Paul Callaghan and Dr Carol Taylor, both awarded substantial Marsden Fund grants this year, were two of five speakers invited by the Royal Society of New Zealand to summarise their research for the guest politicians, ambassadors, members of the science community and the public.

Professor Callaghan talked about his work in polymer physics ­ the deformation of polymers under sheer - and how molecules flow. He drew examples from natural and manmade materials ­ spider silk and sophisticated plastics ­ to show that the key to materials' strength is the way molecules are arranged.

"The most important aspect of this work is that it provides a bridge from the molecule to the macroscopic mechanical world, and from the world of fundamental nuclear and atomic physics, to the world of biology, food science, chemical engineering and medicine, where the mechanical properties of complex soft materials are of such vital importance," Professor Callaghan says.

Dr Taylor's research is about making small versions of a naturally-occurring proteins, large molecules built up of amino acids. Mussels glue themselves to rocks with a strong adhesive protein, and Dr Taylor's group recently completed the assembly of a mini-replica of this protein.

"Building a hamburger is a useful analogy for the way we built the molecule. You assemble half the ingredients on each half of the bun, and the final, challenging step is bringing the two halves together," she says.

The next stage of her research will look at another family of proteins - the collagens. Collagen makes up about one third of the body's protein and is the structural material of skin, teeth, nails, cartilage and bone.

"The collagen molecule is like a molecular rope, with three strands of amino acids wound together to form a tough fibre. By preparing small versions of the collagen molecule, we hope to learn more about how these fibres assemble in nature and extend this to study what goes wrong at the molecular level in collagen-related diseases like arthritis," Dr Taylor says.

College of Sciences Pro Vice Chancellor Professor Robert Anderson said he was delighted that two of the five speakers were from Massey.

"The function was to celebrate leading-edge research achievements and to have two of the speakers from our College of Sciences shows how highly Massey research is regarded," he says.A meeting celebrating science, which starred two top Massey researchers, was hosted at Parliament recently by Science and Technology Minister and Massey Alumnus Pete Hodgson.

Institute of Fundamental Sciences' Professor Paul Callaghan and Dr Carol Taylor, both awarded substantial Marsden Fund grants this year, were two of five speakers invited by the Royal Society of New Zealand to summarise their research for the guest politicians, ambassadors, members of the science community and the public.

Professor Callaghan talked about his work in polymer physics ­ the deformation of polymers under sheer - and how molecules flow. He drew examples from natural and manmade materials ­ spider silk and sophisticated plastics ­ to show that the key to materials' strength is the way molecules are arranged.

"The most important aspect of this work is that it provides a bridge from the molecule to the macroscopic mechanical world, and from the world of fundamental nuclear and atomic physics, to the world of biology, food science, chemical engineering and medicine, where the mechanical properties of complex soft materials are of such vital importance," Professor Callaghan says.

Dr Taylor's research is about making small versions of a naturally-occurring proteins, large molecules built up of amino acids. Mussels glue themselves to rocks with a strong adhesive protein, and Dr Taylor's group recently completed the assembly of a mini-replica of this protein.

"Building a hamburger is a useful analogy for the way we built the molecule. You assemble half the ingredients on each half of the bun, and the final, challenging step is bringing the two halves together," she says.

The next stage of her research will look at another family of proteins - the collagens. Collagen makes up about one third of the body's protein and is the structural material of skin, teeth, nails, cartilage and bone.

"The collagen molecule is like a molecular rope, with three strands of amino acids wound together to form a tough fibre. By preparing small versions of the collagen molecule, we hope to learn more about how these fibres assemble in nature and extend this to study what goes wrong at the molecular level in collagen-related diseases like arthritis," Dr Taylor says.

College of Sciences Pro Vice Chancellor Professor Robert Anderson said he was delighted that two of the five speakers were from Massey.

"The function was to celebrate leading-edge research achievements and to have two of the speakers from our College of Sciences shows how highly Massey research is regarded," he says.

Massey News | 4 December, 2000

 


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