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Arthritis Is A Connective (Collagen) Tissue Disease

Connective Tissue Research

 







 

The Connective Tissue Research Group has been declared a Center of Excellence by the State of Tennessee. 

 

Andrew H. Kang, M.D. has been named as the director of the center of excellence for diseases of connective tissues. Associate directors are Arnold Postlethwaite, M.D. and Dennis Schaberg, M.D. This Center of Excellence will be a comprehensive center for basic clinical and translational research, education and training and community outreach for the State of Tennessee in diseases affecting the joints, cartilage, skeleton and connective tissues of the body. The categories of disease the center will address include classic arthritis associated immune based rheumatic diseases (rheumatoid arthritis, systemic lupus erythematosus, rheumatic fever), degenerative joint disease including the intervertebral discs, osteoporosis, scleroderma and related fibrosing diseases. Components will study etiologic and pathogenetic mechanisms of these diseases by use of animal models and in vitro cell culture systems, development of new diagnostic tests and develop new therapies and prosthetics to treat these diseases. The center will also be a hub for education and training of pre- and post-doctoral fellows in the arthritides and related diseases and will have outreach programs to better educate private physicians in Tennessee and the public about arthritis, bone, joint and connective tissue diseases.




 

Research Trials

 

To view the University of Tennessee Health Science Center and National Institutes of Health (NIH) sponsored research trials involving patients with rheumatoid arthritis or scleroderma please see the links below.

 

 

 

Rheumatoid Arthritis:

 

http://clinicaltrials.gov/ct/gui/show/NCT00000401?order=5&JServSessionIdzone_ct=qr8jb52941

 

Scleroderma:

 

http://clinicaltrials.gov/ct/gui/show/NCT00005675?order=1&JServSessionIdzone_ct=y4w6gv26i1

 

 




 

2002 Symposium on Autoimmune Arthritis, Preliminary Schedule

 

 

The directors of the Center of Excellence for Diseases of Connective Tissues are proud to announce the program for our 2002 International Symposium on Autoimmune Arthritis. The symposium represents a unique opportunity to focus on the immunobiology of autoimmune arthritis with insights provided by internationally recognized researchers in the field. Should you have any questions regarding this symposium, please contact Andrew H Kang. A brochure describing the schedule for the symposium can be found here. Please note that the poster abstract submission deadline of August 1st as listed on the brochure has been extended to September 1st. A PDF version of the registration form for the symposium can be found here.

 






 

 

Pilot and Feasibility Grants

 

Center of Excellence for Diseases of Connective Tissue

 

Purpose:

One of the mandates given to each Center of Excellence is to at least quadruple the research funding in the respective areas over the five year period of the Center funding. As a part of our plan to fulfill this mandate, we are again inviting applications for pilot and feasibility research grant from the Center Of Excellence For Diseases Of Connective Tissue. Pilot and feasibility research grants are available for research in the areas of interest to the Center, i.e. autoimmunity, inflammation and tissue repair, fibrotic disorders, and rheumatic diseases. The research project may be basic, clinical or a combination of both. These grants are intended to facilitate the investigators in these areas to generate research data that would enhance the competitiveness of their projects for external funding, such as RO3, RO21, RO1, projects within Program Project grants or SCOR's, or research career development awards from the NIH or nationally peer-reviewed foundations.

 

Major criteria:

1.              The applicant must be a faculty member in good standing at the UTHSC and currently is, or is interested in becoming, a participating member of the Center Of Excellence For Diseases Of Connective Tissue.

2.              The research project must have high scientific merit.

3.              Potential for successful future peer-reviewed funding must be demonstrated for NIH, other federal or private grants that will accrue indirect cost to the UTHSC.

 

Funding:

Awards range up to $20,000 for one year depending on the needs. The NIH offers pilot study grants such as R21 and RO3 that require only minimal to modest amount of preliminary data. It is hoped that the recipients of the P & F grants should be able to apply for at least these types of grants after 1 year of support.

 

Application procedure:

1.              Each application will be peer-reviewed.

2.              The application should contain the following elements and should ordinarily not exceed five type-written pages (single-spaced) in length.

An editable, PDF version of the application package can be obtained here

i.               Title of the project, name and academic title of the PI

ii.              Introduction and specific aims

iii.            Background and rationale

iv.             Preliminary data if any

v.              Methods of procedure

vi.             Plans for future external funding from NIH, other federal or private sources.

3.              Budget page

4.              CV of the PI (3 page NIH style or its equivalent) with a list of "other support".

Review Criteria:

 

The following criteria will be assessed in arriving at a priority score for the proposed P&F grants.

 

i.               Degree of innovation of the proposal

ii.              Significance of the proposed research and relevance to diseases of connective tissue

iii.            Soundness of the experimental plan

iv.             Investigator potential to obtain funding from government and private foundations that pay indirect costs to the University of Tennessee Health Science Center. For investigators previously funded by a Center of Excellence in Diseases of Connective Tissue P&F grant, whether that P&F grant resulted in submissions or funding of larger grants that return indirect costs to the University of Tennessee Health Science Center.

v.              Research environment

vi.             Human subject use (IRB approval)

vii.           Animal subject use (IACUC approval)

 

Deadline:

Submit 9 copies of the application to Dr. Andrew Kang, Coleman Building Rm. G326, 956 Court Avenue, Memphis, TN 38163 before April 18, 2003. Alternatively, you may submit your application by email to jbaker@utmem.edu. Funding decision will be made within 1 month after the deadline.

 




 

Tweak the mouse to view short primer on the induction of experimental arthritis with type II collagen

(from our chapter submitted to Current Protocols in Immunology



 

Collagen Core Services

 

 

The centers of excellence in connective tissue diseases maintains a core facility for the large-scale purification of collagen, and the production of alpha chains and CB peptides for research in autoimmunity. Presently, these collagens are available from our core service at prices competitive with commercial entities providing this grade of product. If you are interested in further information regarding pricing and availablility of collagen from our core service, please contact the director of this core, David D Brand.

 






 

Collagen amino acid sequences

Chick Type II Collagen CB Peptides


 

CB-Peptides Number of Residues Residue #s
CB1 2 Non-Helical
CB4 13 Non-Helical
CB2 3 1-3
CB3 3 4-6
CB6 33 7-39
CB12 84 40-123
CB11 279 124-402
CB8 149 403-551
CB10 346 552-897
CB5 10 898-907
CB9 73 908-980
CB7 38 981-1018
CB9-7* 111 908-1018


 



Embryonic fibroblast migrating through the developing stromal matrix of a chicken cornea around the 12th day of development ((c) ca. 1970 - D. Hasty)

 

EM of collagen fibrils from chrome tanned cowhide prepared by fragmentation and stained with phosphotungstic acid. The typical axial period is seen as in the shadowed preparation. PTA brings out the characteristic intraperiod structure. Magnification 260,000X. F.O. Schmitt and J. Gross, J. Am. Leather Chem. Assn., XLIII:658,1948

 

David Brand
Last Updated: 9/19/99
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